N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine

Base Information

• Chemical Name: N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine
• CAS No.: 1352803-89-4
• Molecular Formula: C₂₅H₃₂FN₇
• Molecular Weight: 449.574

Synonyms:N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine

Chemical Property of N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine

Chemical Property:

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Technology Process of N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine

There total 3 articles about N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-N₆-methyl-1,3,5-triazine-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.7%

N2-mesityl-N4-methyl-N6-(piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine (1352804-11-5) → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-N6-methyl-1,3,5-triazine-2,4,6-triamine (1352803-89-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

6-chloro-N2-mesityl-N4-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine (1352804-07-9) → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-N6-methyl-1,3,5-triazine-2,4,6-triamine (1352803-89-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 50 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: pH 8

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

4,6-dichloro-N-mesityl-1,3,5-triazin-2-amine → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-N6-methyl-1,3,5-triazine-2,4,6-triamine (1352803-89-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water; acetone / 8 h / 30 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 50 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: pH 8

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2012.02.019

upstream raw materials:

6-chloro-N₂-mesityl-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine

N₂-mesityl-N₄-methyl-N₆-(piperidin-4-yl)-1,3,5-triazine-2,4,6-triamine

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