phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester

Base Information

• Chemical Name: phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester
• CAS No.: 863225-34-7
• Molecular Formula: C₂₀H₃₂NO₆P
• Molecular Weight: 413.451
• Mol file: 863225-34-7.mol

Synonyms:phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester

Chemical Property of phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester

There total 3 articles about phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ5-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one (847672-62-2) → phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester (863225-34-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1.5h; atmospheric pressure;

DOI:10.1021/jm050242f

Reference yield:

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one (847672-61-1) → phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester (863225-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrazole / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

1.2: aq. H₂O₂ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 20 °C

2.1: H₂ / Pd/C / methanol / 1.5 h / 20 °C / atmospheric pressure

With 1H-tetrazole; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm050242f

Reference yield:

fingolimod (162359-55-9) → phosphoric acid mono-{(R/S)-4-[2-(4-octyl-phenyl)-ethyl]-2-oxo-oxazolidin-4-ylmethyl}ester (863225-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. NaOH / 48 h / 20 °C

2.1: tetrazole / CH₂Cl₂; tetrahydrofuran / 18 h / 20 °C

2.2: aq. H₂O₂ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 20 °C

3.1: H₂ / Pd/C / methanol / 1.5 h / 20 °C / atmospheric pressure

With 1H-tetrazole; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jm050242f

upstream raw materials:

(R/S)-4-[2-(4-octylphenyl)ethyl]-4-(3-oxo-1,5-dihydro-3λ⁵-benzo[e][1,3,2]dioxaphosphepin-3-yloxymethyl)oxazolidin-2-one

(R/S)-4-hydroxymethyl-4-[2-(4-octylphenyl)ethyl]oxazolidin-2-one

fingolimod

Downstream raw materials:

fingolimod phosphate