[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

Base Information

Chemical Name:[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid
CAS No.:148747-89-1
Molecular Formula:C₁₈H₁₅N₃O₅S
Molecular Weight:385.4
Hs Code.:

Synonyms:[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

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Chemical Property of [5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

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Technology Process of [5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

There total 6 articles about [5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003-31-2
thiophene-2-carbonitrile

: 148747-89-1
[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / ethanol / 16 h / Ambient temperature

2: methanol / 72 h / 5 °C

3: methanol / 1.5 h / 100 °C

4: pyridine, lithium iodide / 2 h / Heating

5: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

6: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

7: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; triethylamine; lithium iodide; In tetrahydrofuran; methanol; ethanol; tert-butyl alcohol;
DOI:10.1021/jm00001a015

Reference yield:

: 148747-84-6
N-(2,2-Dimethoxy-ethyl)-thiophene-2-carboxamidine

: 148747-89-1
[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 1.5 h / 100 °C

2: pyridine, lithium iodide / 2 h / Heating

3: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

4: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; triethylamine; lithium iodide; In tetrahydrofuran; methanol; tert-butyl alcohol;
DOI:10.1021/jm00001a015

Reference yield:

: 148747-86-8
1-(2,2-dimethoxyethyl)-2-(2-thienyl)pyrimidin-6(1H)-one-5-carboxylic acid

: 148747-89-1
[5-benzyloxycarbonylamino-6-oxo-2-(thien-2-yl)-1,6-dihydro-1-pyrimidinyl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

2: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

3: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; tert-butyl alcohol;
DOI:10.1021/jm00001a015