5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Base Information

Chemical Name:5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide
CAS No.:1616923-37-5
Molecular Formula:C₂₈H₂₉N₃O₄S
Molecular Weight:503.622
Hs Code.:

Synonyms:5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

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Chemical Property of 5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

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Technology Process of 5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

There total 13 articles about 5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1616923-36-4
5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid [2-(tert-butyldimethylsilanyloxy)ethyl]isopropylamide

: 1616923-37-5
5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 30379-55-6
benzyloxyacetic acid

: 1616923-37-5
5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

3: sodium methylate / methanol / 18 h / 0 - 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 24 h / 80 °C

5: pyridine; trichlorophosphate / 2 h / -10 - 0 °C

6: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; thionyl chloride; water; sodium methylate; diisopropylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;

Reference yield:

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 1616923-37-5
5-benzyloxy-6-oxo-2-(4-phenylthiophen-3-ylmethyl)-1,6-dihydropyrimidine-4-carboxylic acid (2-hydroxyethyl)isopropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 2 h / -78 - 20 °C

2: sodium methylate / methanol / 18 h / 0 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 24 h / 80 °C

4: pyridine; trichlorophosphate / 2 h / -10 - 0 °C

5: hydrogenchloride / tetrahydrofuran; water / 1 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; water; sodium methylate; diisopropylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; water;