C₄₁H₆₅N₅O₁₂

Base Information

• Chemical Name: C₄₁H₆₅N₅O₁₂
• CAS No.: 766513-89-7
• Molecular Formula: C₄₁H₆₅N₅O₁₂
• Molecular Weight: 819.993
• Mol file: 766513-89-7.mol

Synonyms:C₄₁H₆₅N₅O₁₂

Chemical Property of C₄₁H₆₅N₅O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₆₅N₅O₁₂

There total 13 articles about C₄₁H₆₅N₅O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C41H67N5O13 (947139-80-2) → C41H65N5O12 (766513-89-7)

Guidance literature:

With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 0 - 20 ℃;

DOI:10.1021/jo070412r

Reference yield:

(3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid (766513-79-5) → C41H65N5O12 (766513-89-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 7 h / -5 °C

2: 100 percent / HCl / ethyl acetate / 2 h / 20 °C

3: 86 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium PF₆^(1-); 1-hydroxybenzotriazole; diisopropylethylamine / CH₂Cl₂; dimethylformamide / -5 °C

4: 96 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

5: 60 percent / HATU; N-methylmorpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium dihydroxide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo070412r

Reference yield:

(3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid methyl ester (766513-78-4) → C41H65N5O12 (766513-89-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / NaOH / methanol; tetrahydrofuran; diethyl ether / 0 - 20 °C

2: 89 percent / 4-(dimethylamino)pyridine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 7 h / -5 °C

3: 100 percent / HCl / ethyl acetate / 2 h / 20 °C

4: 86 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium PF₆^(1-); 1-hydroxybenzotriazole; diisopropylethylamine / CH₂Cl₂; dimethylformamide / -5 °C

5: 96 percent / hydrogen / Pd(OH)2 / methanol / 760.05 Torr

6: 60 percent / HATU; N-methylmorpholine / acetonitrile / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jo070412r

upstream raw materials:

C₄₁H₆₇N₅O₁₃

(3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid

(3S,4R)-4-(tert-butoxycarbonylamino)-5-methyl-3-(tert-butyldimethylsilanyloxy)hexanoic acid methyl ester

N-(N-α-hydroxyisovaleryl-L-leucyl)-L-alanine benzyl ester