(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

Base Information

Chemical Name:(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid
CAS No.:1537168-80-1
Molecular Formula:C₂₅H₂₄F₂N₆O₃
Molecular Weight:494.501
Hs Code.:

Synonyms:(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

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Chemical Property of (3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

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Technology Process of (3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

There total 2 articles about (3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1003845-06-4
(2-chloropyrimidin-5-yl)boronic acid

: 1537169-11-1
6-bromo-3-[2-(difluoromethoxy)benzyl]-2-methylimidazo[1,2-a]pyrazine

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(S)-nipecotic acid

: 1537168-80-1
(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

Guidance literature:: (2-chloropyrimidin-5-yl)boronic acid; (S)-nipecotic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h; Sealed tube; Inert atmosphere;

6-bromo-3-[2-(difluoromethoxy)benzyl]-2-methylimidazo[1,2-a]pyrazine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 80 ℃; for 6h; Inert atmosphere; Sealed tube;

Reference yield:

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(S)-nipecotic acid

: 1537168-80-1
(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2-methylimidazo[1,2-a]pyrazin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C / Sealed tube; Inert atmosphere

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 6 h / 80 °C / Inert atmosphere; Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;