3-benzyloxypropiophenone

Base Information

• Chemical Name: 3-benzyloxypropiophenone
• CAS No.: 37951-47-6
• Molecular Formula: C16H16 O2
• Molecular Weight: 240.302
• Hs Code.: 2914509090
• Mol file: 37951-47-6.mol

Synonyms:Propiophenone,3'-(benzyloxy)- (6CI); Propiophenone, m-(benzyloxy)- (3CI);1-(3-Benzyloxyphenyl)-1-propanone; 3'-(Benzyloxy)propiophenone;m-Benzyloxypropiophenone

Chemical Property of 3-benzyloxypropiophenone

Chemical Property:

• PSA: 26.30000
• LogP: 3.47620
• Storage Temp.: -20°C Freezer
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

3''-BenzyloxyPropiophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3'-Benzyloxy propiophenone is an intermediate used in the production of various ectoparasiticides, drug metabolites and analgesic agents.

Technology Process of 3-benzyloxypropiophenone

There total 4 articles about 3-benzyloxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-(benzyloxy)phenyl)propan-1-ol (49646-55-1) → 3-benzyloxyphenyl ethyl ketone (37951-47-6)

Guidance literature:

With manganese(IV) oxide; In benzene;

DOI:10.1021/jm00265a012

Reference yield:

3-Benzyloxybenzaldehyde (1700-37-4) → 3-benzyloxyphenyl ethyl ketone (37951-47-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Mg

1.2: diethyl ether / 20 °C

2.1: DMSO; (CF₃CO)2O; Et₃N / CH₂Cl₂ / -50 °C

With magnesium; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In dichloromethane; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Swern oxidation;

DOI:10.1002/(SICI)1096-9063(199608)47:4<327::AID-PS432>3.0.CO;2-U

Reference yield:

→ 3-benzyloxyphenyl ethyl ketone (37951-47-6)

Guidance literature:

With potassium dichromate; sulfuric acid;

upstream raw materials:

1-(3-(benzyloxy)phenyl)propan-1-ol

3-Benzyloxybenzaldehyde

Downstream raw materials:

tapentadol

(2S)-3-(dimethylamino)-1-(3-benzyloxyphenyl)-2-methyl-1-propanone

(2S,3R)-1-(dimethylamino)-3-(3-benzyloxyphenyl)-2-methyl-3-pentanol

1-[3-(benzyloxy)phenyl]-3-(dimethylamino)-2-methylpropan-1-one

Refernces

• 1、 -. "CYCLOALKANE DERIVATIVES". . . Retrieved 2008/06/13.