N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

Base Information

Chemical Name:N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride
CAS No.:1372180-05-6
Molecular Formula:C₁₆H₂₂ClFN₂O₃*ClH
Molecular Weight:381.275
Hs Code.:

Synonyms:N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

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Chemical Property of N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

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Technology Process of N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

There total 19 articles about N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1372187-11-5
(6R,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((2-ethoxyacetamido)methyl)-1,4-oxazepane-4-carboxylate

: 1372180-05-6
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2016.05.038

Reference yield:

: 1372187-07-9
(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((methylsulfonyloxy)methyl)-1,4-oxazepane-4-carboxylate

: 1372180-05-6
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: triphenylphosphine; water / tetrahydrofuran / 10 - 35 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran

4: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; sodium azide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; 2: Staudinger Reaction;

Reference yield:

: 1372187-09-1
(6R,7R)-tert-butyl 6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

: 1372180-05-6
N-(((6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)-2-ethoxyacetamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran

2: hydrogenchloride / ethyl acetate / 1 h / 10 - 35 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethyl acetate;