(4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone

Base Information

• Chemical Name: (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone
• CAS No.: 227617-23-4
• Molecular Formula: C₂₁H₁₆ClN₃O₂
• Molecular Weight: 377.83
• Mol file: 227617-23-4.mol

Synonyms:(4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone

Chemical Property of (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone

There total 6 articles about (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

C21H17N3O3 (227617-22-3,557090-80-9) → (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone (227617-23-4)

Guidance literature:

With trichlorophosphate; at 108 ℃; for 1.5h;

Reference yield: 60.0%

5-benzoyl-1-(4-methoxy-benzyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one (227617-22-3,557090-80-9) → (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone (227617-23-4)

Guidance literature:

With trichlorophosphate; at 110 ℃;

DOI:10.1016/S0960-894X(03)00034-9

Reference yield:

4-methyl-benzaldehyde (104-87-0) → (4-Chloro-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-5-yl)phenylmethanone (227617-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NH₂NH₂*H₂O / tetrahydrofuran / 2 h / 0 - 25 °C

1.2: tetrahydrofuran / 2 h / 25 °C

1.3: nBuONa; nBuOH / 3 h / 120 °C

2.1: 1.5 h / 120 °C

2.2: 40 percent / Ph₂O / 1.5 h / 250 °C

3.1: 60 percent / POCl₃ / 110 °C

With hydrazine hydrate; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00034-9

upstream raw materials:

5-benzoyl-1-(4-methoxy-benzyl)-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one

4-methyl-benzaldehyde

ethyl 3-oxo-3-phenylpropionate

1-(4-methoxybenzyl)-1H-pyrazol-5-amine

Downstream raw materials:

SQ-67563

[4-(Butylthio)-1H-pyrazolo[3,4-b]pyridin-5-yl]phenylmethanone

(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-phenyl-methanol