FLUORIDE ON AMBERLYST(R) A-26

Base Information

• Chemical Name: FLUORIDE ON AMBERLYST(R) A-26
• CAS No.: 39339-85-0
• Molecular Formula: C6H4CH2N(CH3)3F
• Molecular Weight: 0
• Hs Code.: 39140000
• Mol file: 39339-85-0.mol

Synonyms:AMBERLYST(R) A-26;AMBERLYST(R) A-26, MACRORETICULAR ION EXCHANGE RESIN;AMBERLITE IRA 900 F-FORM;AMBERLYST A-26 ION EXCHANGE RESIN;AMBERLYST A-26 F-FORM;AMBERLYST A-26;FLUORIDE, POLYMER-SUPPORTED;FLUORIDE ON AMBERLYST(R) A-26

Chemical Property of FLUORIDE ON AMBERLYST(R) A-26

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fluoride on polymer support macroporous, 20-50 mesh, extent of labeling: 2.0-3.0 mmol/g loading ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• General Description: **Fluoride on Amberlyst? A-26** is a polymer-supported fluoride reagent derived from the macroreticular strong anion exchange resin Amberlyst A-26 (or its equivalents, such as Amberlite IRA 900 F-form). It functions as a solid-phase fluoride source, combining the reactivity of fluoride ions with the advantages of heterogeneous catalysis, such as ease of separation and reusability. This reagent is particularly useful in organic synthesis for nucleophilic fluorination, deprotection, or base-promoted reactions, offering improved handling and reduced solubility issues compared to traditional fluoride salts. Its polymeric backbone provides stability and selectivity in various reaction conditions.

Refernces

Efficient and facile synthesis of acrylamide libraries for protein-guided tethering

10.1021/ol503486t

The study reports an efficient and facile method for synthesizing acrylamide libraries from a diverse range of amine fragments using a solid-supported quaternary amine base, specifically ion-exchange resin Amberlyst A26 (OH-form). The acrylamide-modified fragments are used in a kinetic template-guided tethering (KTGT) strategy to discover fragments that bind to defined protein surfaces. The researchers initially attempted standard acylation conditions using acryloyl chloride and triethylamine but encountered low success rates and yields due to acrylamide polymerization and side product formation. By employing Amberlyst A26, they were able to scavenge the HCl generated during the reaction without reacting with acryloyl chloride, thus preventing unwanted side products and achieving higher yields and success rates. This method allowed for the rapid generation of acrylamide libraries suitable for KTGT screening campaigns, enabling the inclusion of greater chemical diversity in the library and offering potential for the development of covalent inhibitors against therapeutic targets.