2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide

Base Information

Chemical Name:2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
CAS No.:371219-74-8
Molecular Formula:C₁₄H₁₅ClN₂O
Molecular Weight:262.739
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50394183
Pharos Ligand ID:63JLVQKYX19F
ChEMBL ID:CHEMBL446446
Mol file:371219-74-8.mol

Synonyms:371219-74-8;2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide;2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide;CHEMBL446446;Oprea1_323938;MLS001163802;SCHEMBL1873844;DTXSID50394183;ABIVOOWWGYJNLV-UHFFFAOYSA-N;HMS2873H18;WPA21974;BDBM50178766;MFCD00846509;STK524333;AKOS005458227;SB36878;PD086083;SMR000539218;CS-0065297;FT-0701854;2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide

Suppliers and Price of 2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylicacidamide 96%
50mg
$ 156.00

Crysdot
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide 95+%
1g
$ 762.00

American Custom Chemicals Corporation
2-CHLORO-5,6,7,8,9,10-HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE 95.00%
500MG
$ 784.25

Alichem
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
1g
$ 638.60

Total 11 raw suppliers

Chemical Property of 2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide

Chemical Property:

PSA：58.88000
LogP:3.81690
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:262.0872908
Heavy Atom Count:18
Complexity:336

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylicacidamide 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2=C(C(C1)C(=O)N)NC3=C2C=C(C=C3)Cl

Technology Process of 2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide

There total 3 articles about 2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 871586-90-2
methyl 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylate

: 371219-74-8,848193-72-6
2-chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide

Guidance literature:: With ammonia; In methanol; at 90 ℃; for 48h; Inert atmosphere;

Reference yield:

: 871586-89-9
methyl 3-bromo-2-oxo-1-cycloheptanecarboxylate

: 371219-74-8,848193-72-6
2-chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 140 °C

2: 2 g / NH₃ / methanol / 48 h / 90 °C

With ammonia; In methanol;
DOI:10.1021/jm050522v

Reference yield:

: 52784-32-4
2-(methoxycarbonyl)cycloheptanone

: 371219-74-8,848193-72-6
2-chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: Br₂ / CCl₄ / 96 h / 20 °C

2: 140 °C

3: 2 g / NH₃ / methanol / 48 h / 90 °C

With ammonia; bromine; In methanol; tetrachloromethane;
DOI:10.1021/jm050522v