tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
CAS No.:944472-31-5
Molecular Formula:C₃₁H₃₄BrN₅O₁₀S₂
Molecular Weight:780.674
Hs Code.:

tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Synonyms:tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Chemical Property of tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Technology Process of tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

There total 11 articles about tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944472-28-0
tert-butyl (4S)-4-{4-[({(1S)-2-hydroxy-1-[4-(methoxymethyl)-1,3-triazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: C₁₀H₅BrNO₄Cl

: 944472-31-5
tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 25 ℃; for 2h;
DOI:10.1016/j.tet.2007.03.072

Reference yield:

: 850694-33-6
methyl 3-(2'-bromo-6'-nitrophenyl)-2-oxobut-3-enoate

: 944472-31-5
tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / Me₃SnOH / 1,2-dichloro-ethane / 0.33 h / 80 °C

2: oxalyl chloride; DMF / tetrahydrofuran / 0.75 h / 0 °C

3: 12 mg / Et₃N / tetrahydrofuran / 2 h / 0 - 25 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; trimethyltin(IV) hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.tet.2007.03.072

Reference yield:

: 850694-42-7
3-(2-bromo-6-nitro-phenyl)-2-oxo-but-3-enoic acid

: 944472-31-5
tert-butyl (4S)-4-{4-[({(1S)-2-{[3-(2-bromo-6-nitrophenyl)-2-oxobut-3-enoyl]oxy}-1-[4-(methoxymethyl)-1,3-thiazol-2-yl]ethyl}amino)carbonyl]-1,3-thiazol-2-yl}-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / tetrahydrofuran / 0.75 h / 0 °C

2: 12 mg / Et₃N / tetrahydrofuran / 2 h / 0 - 25 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.tet.2007.03.072