N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

Base Information

Chemical Name:N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide
CAS No.:914933-44-1
Molecular Formula:C₃₀H₄₂N₂O₅Si₂
Molecular Weight:566.845
Hs Code.:

<i>N</i>-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

Synonyms:N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

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Chemical Property of N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

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Technology Process of N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

There total 12 articles about N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914933-43-0
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

: 914933-44-1
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.200602050

Reference yield:

: 914933-37-2
2-[2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetylamino]-3-hydroxy-propionic acid methyl ester

: 914933-44-1
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole; DMAP / dimethylformamide / 0.75 h / 20 °C

2: 80 percent / LiCl; NaBH₄ / methanol; tetrahydrofuran / 19 h / 20 °C

3: NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium hydrogencarbonate; Dess-Martin periodane; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.200700033

Reference yield:

: 914933-53-2
(S)-3-(tert-butyldimethylsilyloxy)-2-[(S)-2-(tert-butyldiphenylsilyloxy)-2-oxazol-5-ylacetylamino]propionic acid methyl ester

: 914933-44-1
N-[2-(tert-butyl-dimethyl-silanyloxy)-1-formyl-ethyl]-2-(tert-butyl-diphenyl-silanyloxy)-2-oxazol-5-yl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / LiCl; NaBH₄ / methanol; tetrahydrofuran / 19 h / 20 °C

2: NaHCO₃; Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; Dess-Martin periodane; lithium chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.200700033