(R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine

Base Information

• Chemical Name: (R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine
• CAS No.: 336850-33-0
• Molecular Formula: C₂₀H₂₁ClN₂O₃
• Molecular Weight: 372.851
• Mol file: 336850-33-0.mol

Synonyms:(R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine

Chemical Property of (R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine

There total 1 articles about (R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-tert-butyloxycarbonyl-3-(4-cyanophenyl)oxaziridine (150884-56-3,158807-35-3) + C-benzofuran-2-yl-C-(4-chloro-phenyl)-methylamine (249297-72-1) → (R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine (336850-33-0)

Guidance literature:

In chloroform; at 20 ℃; for 26h;

DOI:10.1016/S0957-4166(00)00486-9

Reference yield: 55.0%

(R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine (336850-33-0) → (R)-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine dihydrochloride

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0957-4166(00)00486-9

Reference yield:

(R)-1-(tert-butoxycarbonyl)-2-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]hydrazine (336850-33-0) → (R)-(+)-1-[α-(benzofuran-2-yl)-(4-chlorophenyl)methyl]-1H-1,2,4-triazole

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / HCl(gas) / diethyl ether / 2 h / 0 - 20 °C

2: ethanol / 10 h / Heating

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1016/S0957-4166(00)00486-9

upstream raw materials:

N-tert-butyloxycarbonyl-3-(4-cyanophenyl)oxaziridine

C-benzofuran-2-yl-C-(4-chloro-phenyl)-methylamine