3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Base Information

Chemical Name:3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione
CAS No.:1335109-17-5
Molecular Formula:C₂₅H₂₆ClN₅O₂
Molecular Weight:463.967
Hs Code.:

Synonyms:3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

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Chemical Property of 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

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Technology Process of 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

There total 5 articles about 3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂ClN₅O₃

: 1335109-17-5
3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:: C₂₇H₃₂ClN₅O₃; With potassium hydroxide; In methanol; for 2h; Reflux;

With acetic acid; In methanol; at 22 ℃; pH=4;
DOI:10.1016/j.bmc.2011.06.043

Reference yield:

: 1335106-73-4
N-[2-cyano-2-(4-methylphenyl)ethenyl]glycine ethyl ester

: 1335109-17-5
3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; sodium / 48 h / 22 °C

2.1: toluene / 6 h / Reflux

3.1: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 96 h / Reflux

4.1: potassium hydroxide / methanol / 2 h / Reflux

4.2: 22 °C / pH 4

With ethanol; sodium; sodium hydrogencarbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmc.2011.06.043

Reference yield:

: 1335106-83-6
3-[[[(2-chloroethyl)amino]carbonyl]amino]-4-(4-methylphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

: 1335109-17-5
3-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]-7-(4-methylphenyl)-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 96 h / Reflux

2.1: potassium hydroxide / methanol / 2 h / Reflux

2.2: 22 °C / pH 4

With sodium hydrogencarbonate; sodium iodide; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.06.043