2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Base Information

• Chemical Name: 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine
• CAS No.: 199793-00-5
• Molecular Formula: C₄₀H₃₈N₆O₉
• Molecular Weight: 746.777

Synonyms:2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Chemical Property of 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

There total 6 articles about 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-N6-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine (199792-91-1) → 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N6-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine (199793-00-5)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 288h;

DOI:10.1002/1522-2675(20000809)83:8<2023::AID-HLCA2023>3.0.CO;2-P

Reference yield: 95.0%

Carbonic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(5-dimethylamino-naphthalene-1-sulfonyl)-ethyl ester (199792-97-7) → 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N6-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine (199793-00-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.0166667h;

DOI:10.1080/07328319708006249

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N6-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine (199793-00-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / CH₂Cl₂ / 32 h / 20 °C

2: 95 percent / DBU / acetonitrile / 0.02 h / 20 °C

With pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile; 1: Condensation / 2: Elimination;

DOI:10.1002/1522-2675(20000809)83:8<2023::AID-HLCA2023>3.0.CO;2-P

upstream raw materials:

2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Carbonic acid (2R,3S,5R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(5-dimethylamino-naphthalene-1-sulfonyl)-ethyl ester

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Downstream raw materials:

2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine 5'-(hydrogen butanedioate)

2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine 5'-(2-cyanoethyl diisopropylphosphoramidite)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 199793-00-5 2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send