[1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate

Base Information

• Chemical Name: [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate
• CAS No.: 1335100-76-9
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₃N₃O₄
• Molecular Weight: 507.466
• Mol file: 1335100-76-9.mol

Synonyms:[1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate

Chemical Property of [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate

There total 7 articles about [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{6-[4-(1-boc-piperidin-4-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}acetic acid (1353054-10-0) + trifluoroacetic acid (76-05-1) → [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate (1335100-76-9)

Guidance literature:

In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2011.07.063

Reference yield:

(6-nitro-1-oxo-1,3-dihydroisoindol-2-yl)acetic acid methyl ester (1146295-07-9) → [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate (1335100-76-9)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / methanol / 7 h / 20 °C

2: triethylamine; HATU / 20 °C

3: sodium hydroxide / methanol; water / 20 °C

4: dichloromethane / 2 h / 0 °C

With palladium on activated charcoal; hydrogen; triethylamine; HATU; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.07.063

Reference yield:

{6-[4-(1-boc-piperidin-4-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}acetic acid methyl ester (1353053-84-5) → [1-oxo-6-(4-piperidinium-4-yl-benzoylamino)-1,3-dihydroisoindol-2-yl]acetic acid trifluoroacetate (1335100-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 20 °C

2: dichloromethane / 2 h / 0 °C

With sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.07.063

upstream raw materials:

(6-nitro-1-oxo-1,3-dihydroisoindol-2-yl)acetic acid methyl ester

(6-amino-1-oxo-1,3-dihydroisoindol-2-yl)acetic acid methyl ester

{6-[4-(1-boc-piperidin-4-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}acetic acid methyl ester

{6-[4-(1-boc-piperidin-4-yl)benzoylamino]-1-oxo-1,3-dihydroisoindol-2-yl}acetic acid