(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

Base Information

Chemical Name:(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile
CAS No.:1609280-46-7
Molecular Formula:C₂₇H₂₃FN₈O
Molecular Weight:494.531
Hs Code.:

Synonyms:(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

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Chemical Property of (Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

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Technology Process of (Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

There total 4 articles about (Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1609280-35-4
6-((4-(4-aminophenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

: 459-57-4
4-fluorobenzaldehyde

: 1609280-46-7
(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

Guidance literature:: In toluene; Inert atmosphere; Schlenk technique; Reflux;
DOI:10.1016/j.ejmech.2014.03.085

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1609280-46-7
(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / 0 - 5 °C / Inert atmosphere; Schlenk technique

2: acetone / 12 h / 30 °C / Inert atmosphere; Schlenk technique

3: potassium phosphate; palladium diacetate; XPhos / toluene / 13 h / 100 °C / Inert atmosphere

4: toluene / Inert atmosphere; Schlenk technique; Reflux

With potassium phosphate; palladium diacetate; potassium carbonate; XPhos; In acetone; toluene; 3: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.085

Reference yield:

: 1609280-33-2
6-((4-chloro-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

: 1609280-46-7
(Z)-6-((4-(4-(4-fluorobenzylideneamino)phenyl)-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-yl)oxy)nicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; palladium diacetate; XPhos / toluene / 13 h / 100 °C / Inert atmosphere

2: toluene / Inert atmosphere; Schlenk technique; Reflux

With potassium phosphate; palladium diacetate; XPhos; In toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2014.03.085