α-ethyl D-N-carbobenzoxyglutamate

Base Information

Chemical Name:α-ethyl D-N-carbobenzoxyglutamate
CAS No.:97996-97-9
Molecular Formula:C₁₅H₁₉NO₆
Molecular Weight:309.319
Hs Code.:

Synonyms:α-ethyl D-N-carbobenzoxyglutamate

Suppliers and Price of α-ethyl D-N-carbobenzoxyglutamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of α-ethyl D-N-carbobenzoxyglutamate

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of α-ethyl D-N-carbobenzoxyglutamate

There total 1 articles about α-ethyl D-N-carbobenzoxyglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97997-00-7
α-ethyl D-N-carbobenzoxyglutamate dicyclohexylamine salt

: 97996-97-9
α-ethyl D-N-carbobenzoxyglutamate

Guidance literature:: DOI:10.1248/cpb.37.2417

Reference yield: 90.0%

: 97996-97-9
α-ethyl D-N-carbobenzoxyglutamate

: 153-94-6,27732-43-0,80206-30-0,27813-82-7
D-tryptophan

: 1382326-14-8
Cbz-D-Glu(D-Trp-OH)-O-Et

Guidance literature:: α-ethyl D-N-carbobenzoxyglutamate; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice-water;

D-tryptophan; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice-water;

With hydrogenchloride; In water; N,N-dimethyl-formamide; Cooling with ice;

Reference yield:

: 97996-97-9
α-ethyl D-N-carbobenzoxyglutamate

: 127413-73-4
(2S,3aS,7aS)-1-(N-benzyloxycarbonyl-L-histidyl-γ-D-glutamyl)-octahydro-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 34.1 g / triethylamine, EDC*HCl / CH₂Cl₂

2: 87 percent / H₂ / 10percent Pd/C / acetic acid; 2-methyl-propan-2-ol / 4 h

3: 0.7 g / EDC*HCl / tetrahydrofuran; CH₂Cl₂ / 6 h

4: 11 percent / 1N NaOH / dioxane / 4 h

With sodium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; tert-butyl alcohol;
DOI:10.1248/cpb.37.2417