9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Base Information

• Chemical Name: 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one
• CAS No.: 177779-55-4
• Molecular Formula: C₃₁H₃₀N₄O₅
• Molecular Weight: 538.603

Synonyms:9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Chemical Property of 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

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Technology Process of 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

There total 4 articles about 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Imidazole-1-carbothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl] ester (177779-54-3) → 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one (177779-55-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,4-dioxane; for 1h; Heating;

DOI:10.1080/07328319608002035

Reference yield:

2-deoxyinosine (890-38-0) → 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one (177779-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine

2: dimethylformamide / 20 h

3: 84 percent / tri-n-butyltin hydride, azobisisobutyronitrile / dioxane / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002035

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one (177779-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine

2: dimethylformamide / 20 h

3: 84 percent / tri-n-butyltin hydride, azobisisobutyronitrile / dioxane / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;

DOI:10.1080/07328319608002035

upstream raw materials:

Imidazole-1-carbothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl] ester

2-deoxyinosine

4,4'-dimethoxytrityl chloride

9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

Downstream raw materials:

5'-O-acetyl-2',3'-dideoxyinosine

Dideoxyinosine

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