2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

Base Information

Chemical Name:2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide
CAS No.:1262282-47-2
Molecular Formula:C₁₈H₂₇NO₃Si
Molecular Weight:333.503
Hs Code.:

Synonyms:2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

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Technology Process of 2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

There total 2 articles about 2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 294190-47-9
2-iodo-N-methoxy-N-methyl-benzamide

: 1262282-47-2
2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; In tetrahydrofuran; for 2h; Inert atmosphere;
DOI:10.1021/ol1029035

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 1262282-47-2
2-[3-[(tert-butyldimethylsilyl)oxy]-prop-1-ynyl]-N-methoxy-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 12 h / 0 - 25 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / tetrahydrofuran / 2 h / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; N-butylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol1029035