2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 101747-06-2
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288.343
• Mol file: 101747-06-2.mol

Synonyms:2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester

Chemical Property of 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester

There total 3 articles about 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl acetoacetate (141-97-9) + ethyl (2E)-5-phenylpent-2-enoate (55282-95-6) → 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester (101747-06-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 6h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.03.042

Reference yield:

3-phenyl-propionaldehyde (104-53-0) → 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester (101747-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloromethane / 0.33 h / 20 °C

1.2: 15 h

2.1: sodium ethanolate / ethanol / 6 h / Reflux; Inert atmosphere

With sodium ethanolate; potassium carbonate; In ethanol; dichloromethane;

DOI:10.1016/j.tetlet.2013.03.042

Reference yield:

(+/-)-2,4-dioxo-6-trans-styryl-cyclohexanecarboxylic acid ethyl ester (101595-36-2) → 2,4-dioxo-6-phenethyl-cyclohexanecarboxylic acid ethyl ester (101747-06-2)

Guidance literature:

With ethanol; palladium; Hydrogenation;

DOI:10.1039/jr9560003001

upstream raw materials:

(+/-)-2,4-dioxo-6-trans-styryl-cyclohexanecarboxylic acid ethyl ester

ethyl acetoacetate

ethyl (2E)-5-phenylpent-2-enoate

3-phenyl-propionaldehyde

Downstream raw materials:

2,4-dihydroxy-6-phenethyl-benzoic acid ethyl ester