methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

Base Information

Chemical Name:methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate
CAS No.:911128-93-3
Molecular Formula:C₂₀H₁₃FINO₄
Molecular Weight:477.23
Hs Code.:

Synonyms:methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

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Chemical Property of methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

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Technology Process of methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

There total 8 articles about methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 911129-07-2
methyl 3-(aminocarbonyl)-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

: 911128-93-3
methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

Guidance literature:: With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.06.090

Reference yield:

: 1007600-37-4
2-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-succinic acid

: 911128-93-3
methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: aq. H₂SO₄ / 18 h / Heating

2: 82 percent / NaOMe / methanol / 3.5 h / Heating

3: thionyl chloride / tetrahydrofuran; dimethylformamide / 2 h / Heating

4: 14.9 g / aq. NH₃ / tetrahydrofuran; dimethylformamide / 2 h / cooling

5: 91 percent / oxalyl chloride / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

With ammonium hydroxide; thionyl chloride; oxalyl dichloride; sulfuric acid; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2: Stobbe condensation;
DOI:10.1016/j.tet.2006.06.090

Reference yield:

: (E)-3-Chlorocarbonyl-4-(4-fluoro-phenyl)-2-[1-(4-iodo-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-but-3-enoic acid methyl ester

: 911128-93-3
methyl 3-cyano-4-(4-fluorophenyl)-2-[(4-iodo-1,3-benzodioxol-5-yl)methylene]but-3-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 14.9 g / aq. NH₃ / tetrahydrofuran; dimethylformamide / 2 h / cooling

2: 91 percent / oxalyl chloride / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

With ammonium hydroxide; oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.06.090