(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide
CAS No.:1326776-97-9
Molecular Formula:C₃₀H₃₄F₃NO₂Si
Molecular Weight:525.686
Hs Code.:

Synonyms:(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

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Chemical Property of (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

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Technology Process of (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

There total 5 articles about (S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1326776-70-8
C₂₈H₃₅NOSi

: 407-25-0
trifluoroacetic anhydride

: 1326776-97-9
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

Guidance literature:: With pyridine; In dichloromethane; at 25 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo201215c

Reference yield:

: 1326776-46-8
(S)-(E)-methyl 4-((tert-butoxycarbonyl)amino)-2-methyl-5-phenylpent-2-enoate

: 1326776-97-9
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 5 h / -50 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 3 h / 25 °C / Inert atmosphere

With pyridine; 1H-imidazole; diisobutylaluminium hydride; trifluoroacetic acid; In hexane; dichloromethane;
DOI:10.1021/jo201215c

Reference yield:

: 1266130-89-5
(S)-(E)-tert-butyl (5-hydroxy-4-methyl-1-phenylpent-3-en-2-yl)carbamate

: 1326776-97-9
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methyl-1-phenylpent-3-en-2-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 3 h / 25 °C / Inert atmosphere

With pyridine; 1H-imidazole; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo201215c