Technology Process of (S)-3-Benzyloxy-3-((4S,5R)-4-benzyloxymethyl-5-isopropenyl-2,2-dimethyl-[1,3]dioxan-4-yl)-propionaldehyde
There total 12 articles about (S)-3-Benzyloxy-3-((4S,5R)-4-benzyloxymethyl-5-isopropenyl-2,2-dimethyl-[1,3]dioxan-4-yl)-propionaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-methyl-2-indolinone;
tetrapropylammonium perruthennate;
DOI:10.1021/jo9810563
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: m-CPBA; BF3*Et2O
2.1: LiAlH4
3.1: imidazole
4.1: Swern oxidation
5.1: LDA / tetrahydrofuran / -78 °C
5.2: tetrahydrofuran / 0.17 h / -78 °C
6.1: DIBAL-H
7.1: CSA
8.1: TBAF / tetrahydrofuran
9.1: 77 percent / NMO / TPAP
With
1H-imidazole; lithium aluminium tetrahydride; N-methyl-2-indolinone; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
tetrapropylammonium perruthennate;
In
tetrahydrofuran;
1.1: Oxidation / 2.1: Reduction / 3.1: silylation / 4.1: Swern oxidation / 5.1: Metallation / 5.2: Addition / 6.1: Reduction / 7.1: Cyclization / 8.1: desilylation / 9.1: Oxidation;
DOI:10.1021/jo9810563
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: HCl
2.1: NaH
3.1: m-CPBA; BF3*Et2O
4.1: LiAlH4
5.1: imidazole
6.1: Swern oxidation
7.1: LDA / tetrahydrofuran / -78 °C
7.2: tetrahydrofuran / 0.17 h / -78 °C
8.1: DIBAL-H
9.1: CSA
10.1: TBAF / tetrahydrofuran
11.1: 77 percent / NMO / TPAP
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; N-methyl-2-indolinone; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
tetrapropylammonium perruthennate;
In
tetrahydrofuran;
1.1: Cyclization / 2.1: Etherification / 3.1: Oxidation / 4.1: Reduction / 5.1: silylation / 6.1: Swern oxidation / 7.1: Metallation / 7.2: Addition / 8.1: Reduction / 9.1: Cyclization / 10.1: desilylation / 11.1: Oxidation;
DOI:10.1021/jo9810563
![(S)-3-Benzyloxy-3-((4S,5R)-4-benzyloxymethyl-5-isopropenyl-2,2-dimethyl-[1,3]dioxan-4-yl)-propan-1-ol](/Databaselist/images/loading.webp)
