(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

Base Information

Chemical Name:(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol
CAS No.:262594-20-7
Molecular Formula:C₂₆H₄₀O₃
Molecular Weight:400.602
Hs Code.:

Synonyms:(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

There total 10 articles about (1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 262594-21-8
3,5-di[(tert-butyldimethylsilyl)oxy]-1-ethynylcyclohex-1-ene

: 222317-53-5
25-trimethylsilyloxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate

: 262594-20-7
(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

Guidance literature:: 3,5-di[(tert-butyldimethylsilyl)oxy]-1-ethynylcyclohex-1-ene; 25-trimethylsilyloxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate; With copper(l) iodide; bis(triphenylphosphine) palladium (Il) acetate; diethylamine; In N,N-dimethyl-formamide;

With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(99)02152-8

Reference yield:

: 77-95-2
D-(-)-quinic acid

: 262594-20-7
(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

Guidance literature:: Multi-step reaction with 10 steps

1.1: 57 percent

2.1: 80 percent / POCl₃; pyridine

3.1: 84 percent / TBAF / tetrahydrofuran

4.1: 98 percent / PPh₃; DIAD / tetrahydrofuran

5.1: 83 percent / MeONa / methanol

6.1: 95 percent / imidazole / CH₂Cl₂

7.1: 96 percent / DIBAL-H / toluene

8.1: 98 percent / PCC / CH₂Cl₂

9.1: 70 percent / BuLi / tetrahydrofuran

10.1: Pd(PPh₃)2(OAc)2*CuI; Et₂NH / dimethylformamide

10.2: 85 percent / TBAF / tetrahydrofuran

With pyridine; 1H-imidazole; copper(l) iodide; n-butyllithium; bis(triphenylphosphine) palladium (Il) acetate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium methylate; diisobutylaluminium hydride; diethylamine; triphenylphosphine; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Dehydration / 3.1: Hydrolysis / 4.1: Acylation / 5.1: deprotection / 6.1: Etherification / 7.1: Reduction / 8.1: Oxidation / 9.1: Condensation / 10.1: Condensation / 10.2: deprotection;
DOI:10.1016/S0040-4039(99)02152-8

Reference yield:

: 139356-33-5
(3S,5S)-3,5-bis[(tert-butyl)dimethylsilyloxy]-1-hydroxycyclohexane-1-carboxylic acid methyl ester

: 262594-20-7
(1R,3R)-5-[(1R,3aR,7aR)-1-((R)-5-Hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-ylethynyl]-cyclohex-4-ene-1,3-diol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 80 percent / POCl₃; pyridine

2.1: 84 percent / TBAF / tetrahydrofuran

3.1: 98 percent / PPh₃; DIAD / tetrahydrofuran

4.1: 83 percent / MeONa / methanol

5.1: 95 percent / imidazole / CH₂Cl₂

6.1: 96 percent / DIBAL-H / toluene

7.1: 98 percent / PCC / CH₂Cl₂

8.1: 70 percent / BuLi / tetrahydrofuran

9.1: Pd(PPh₃)2(OAc)2*CuI; Et₂NH / dimethylformamide

9.2: 85 percent / TBAF / tetrahydrofuran

With pyridine; 1H-imidazole; copper(l) iodide; n-butyllithium; bis(triphenylphosphine) palladium (Il) acetate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium methylate; diisobutylaluminium hydride; diethylamine; triphenylphosphine; pyridinium chlorochromate; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Dehydration / 2.1: Hydrolysis / 3.1: Acylation / 4.1: deprotection / 5.1: Etherification / 6.1: Reduction / 7.1: Oxidation / 8.1: Condensation / 9.1: Condensation / 9.2: deprotection;
DOI:10.1016/S0040-4039(99)02152-8