N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

Base Information

Chemical Name:N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide
CAS No.:1616599-75-7
Molecular Formula:C₂₂H₂₃ClFN₃O₅
Molecular Weight:463.893
Hs Code.:

N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

Synonyms:N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

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Chemical Property of N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

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Technology Process of N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

There total 20 articles about N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉ClFN₃O₅

: 1616599-75-7
N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; In chloroform; at 20 ℃; for 3h;

Reference yield:

: 1332856-04-8
l

: 1616599-75-7
N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 0.38 h / -70 °C / Inert atmosphere

1.2: 0.42 h / Inert atmosphere

2.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C

3.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice

3.2: -50 - 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

4.2: 2 h / 80 °C

4.3: 2 h / 110 °C

5.1: hydrogen bromide / water; 1,4-dioxane / 3 h / 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

7.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 3.53 h

7.2: 0.5 h / 20 °C

8.1: hydrogenchloride; trifluoroacetic acid / chloroform / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; ethylbenzene; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1332856-05-9
C₂₀H₂₂O₇

: 1616599-75-7
N-(3-chloro-2-fluorobenzyl)-9’-hydroxy-cis-3-(methoxymethyl)-2’-methyl-1’,8’-dioxo-1’,2’,3’,8’-tetrahydrospiro[cyclobutane-1,4’-pyrido[1,2-a]pyrazine]-7’-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / ethyl acetate / 1 h / 20 °C

2.1: oxalyl dichloride / chloroform; N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice

2.2: -50 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.2: 2 h / 80 °C

3.3: 2 h / 110 °C

4.1: hydrogen bromide / water; 1,4-dioxane / 3 h / 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

6.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane / 3.53 h

6.2: 0.5 h / 20 °C

7.1: hydrogenchloride; trifluoroacetic acid / chloroform / 3 h / 20 °C

With hydrogenchloride; oxalyl dichloride; water; hydrogen bromide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;