diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate
CAS No.:126632-41-5
Molecular Formula:C₃₀H₄₀N₆O₁₀
Molecular Weight:644.682
Hs Code.:

Synonyms:diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

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Technology Process of diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

There total 3 articles about diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 126632-41-5
diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

2: 99 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 2068.6 Torr

3: 1.) glacial acetic acid, 3A-sieves, 2.) NaBH₃CN / 1.) EtOH, 25 deg C, 2 h 40 min, 2.) EtOH, RT, 23 h

With 4-methyl-morpholine; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00086a008

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 126632-41-5
diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-hydroxybenzotriazole (HOBT), 1,3-dicyclohexylcarbodiimide (DCC), 2.) N-methylmorpholine / 1.) CH₂Cl₂, DMF, 1 h, 2.) CH₂Cl₂, DMF, 76 h

2: 99 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 2068.6 Torr

3: 1.) glacial acetic acid, 3A-sieves, 2.) NaBH₃CN / 1.) EtOH, 25 deg C, 2 h 40 min, 2.) EtOH, RT, 23 h

With 4-methyl-morpholine; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00086a008

Reference yield:

: 126632-39-1
diethyl N-(3-methoxy-4-nitrobenzoyl)-L-glutamate

: 126632-41-5
diethyl N-<4-<<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propyl>amino>-3-methoxybenzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / ethanol / 1.5 h / 2068.6 Torr

2: 1.) glacial acetic acid, 3A-sieves, 2.) NaBH₃CN / 1.) EtOH, 25 deg C, 2 h 40 min, 2.) EtOH, RT, 23 h

With 3 A molecular sieve; hydrogen; sodium cyanoborohydride; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00086a008