2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Name:2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS No.:1374239-75-4
Molecular Formula:C₂₃H₂₀Cl₂N₆O
Molecular Weight:467.357
Hs Code.:

Synonyms:2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Property of 2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Technology Process of 2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 6 articles about 2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1374243-34-1
2-(3,5-dichlorophenylamino)-1-(4-(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1374239-75-4
2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With water; potassium carbonate; In methanol; at 60 ℃; for 2h;

Reference yield:

: 23687-25-4
4-aminoisoquinoline

: 1374239-75-4
2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 0 - 100 °C

2: hydrogen; acetic acid / platinum(IV) oxide / 10 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

4: potassium carbonate; water / methanol / 2.5 h / Reflux

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 90 °C

6: potassium carbonate; water / methanol / 2 h / 60 °C

With water; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In pyridine; methanol; N,N-dimethyl-formamide;

Reference yield:

: 2,2,2-trifluoro-N-(isoquinolin-4-yl)acetamide

: 1374239-75-4
2-(3,5-dichlorophenylamino)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; acetic acid / platinum(IV) oxide / 10 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

3: potassium carbonate; water / methanol / 2.5 h / Reflux

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 90 °C

5: potassium carbonate; water / methanol / 2 h / 60 °C

With water; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In methanol; N,N-dimethyl-formamide;