(5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester
CAS No.:369638-71-1
Molecular Formula:C₁₀H₁₆N₄O₂
Molecular Weight:224.263
Hs Code.:
Mol file:369638-71-1.mol

Synonyms:(5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Suppliers and Price of (5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.571
Boiling Point:315.353°C at 760 mmHg
Flash Point:144.521°C
PSA：93.62000
Density:1.213g/cm³
LogP:1.99620

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

There total 4 articles about (5-Aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 369638-70-0
(5-azidomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

: 369638-71-1
(5-aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;
DOI:10.1016/S0960-894X(02)00129-4

Reference yield:

: 5521-55-1
2-methylpyrazin-5-carboxylic acid

: 369638-71-1
(5-aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: DPPA; Et₃N / dioxane / 100 °C

1.2: 70 percent / 25 h

2.1: 54 percent / NBS; (PhCO₂)2; NaHCO₃ / CCl₄ / Heating

3.1: 98 percent / NaN₃ / dimethylformamide / 5 h / 20 °C

4.1: 98 percent / H₂ / Pd/C / methanol / 760 Torr

With N-Bromosuccinimide; sodium azide; diphenyl-phosphinic acid; hydrogen; sodium hydrogencarbonate; triethylamine; dibenzoyl peroxide; palladium on activated charcoal; In 1,4-dioxane; methanol; tetrachloromethane; N,N-dimethyl-formamide; 1.1: Curtius rearrangement;
DOI:10.1016/S0960-894X(02)00129-4

Reference yield:

: 369638-68-6
tert-butyl (5-methylpyrazin-2-yl)carbamate

: 369638-71-1
(5-aminomethyl-pyrazin-2-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / NBS; (PhCO₂)2; NaHCO₃ / CCl₄ / Heating

2: 98 percent / NaN₃ / dimethylformamide / 5 h / 20 °C

3: 98 percent / H₂ / Pd/C / methanol / 760 Torr

With N-Bromosuccinimide; sodium azide; hydrogen; sodium hydrogencarbonate; dibenzoyl peroxide; palladium on activated charcoal; In methanol; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00129-4