ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

Base Information

Chemical Name:ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate
CAS No.:188548-20-1
Molecular Formula:C₂₁H₂₇NO₅
Molecular Weight:373.449
Hs Code.:

Synonyms:ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

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Chemical Property of ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

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Technology Process of ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

There total 8 articles about ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 188548-03-0
ethyl 4-methylene-2-(2-phenylethyl)pyroglutamate

: 188548-20-1
ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

Guidance literature:: With dmap; In acetonitrile; for 12h;

Reference yield:

: 17376-04-4
2-phenethyl iodide

: 188548-20-1
ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (Me₃Si)2NH, n-BuLi / 1.) THF, hexane, from -78 deg C to 25 deg C, 1 h, 2.) THF, hexane, 0 deg C, 1 h

2: 99 percent / 4-(dimethylamino)pyridine / acetonitrile / 12 h

With dmap; n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 188548-20-1
ethyl N-(tert-butoxycarbonyl)-2-(2-phenylethyl)-4-methylenepyroglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-(dimethylamino)pyridine / acetonitrile / 12 h

2: 1.) LHMDS, 3.) MeI, 4.) NaHCO₃

With dmap; sodium hydrogencarbonate; lithium hexamethyldisilazane; methyl iodide; In acetonitrile;