3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Base Information

Chemical Name:3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride
CAS No.:1065481-72-2
Molecular Formula:C₁₇H₁₃ClFNO*ClH
Molecular Weight:338.209
Hs Code.:

Synonyms:3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Suppliers and Price of 3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

There total 3 articles about 3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1065481-73-3
(2-(3-fluorophenyl)-8-methoxyquinolin-3-yl)methanol

: 1065481-72-2
3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Guidance literature:: With thionyl chloride; In chloroform; at 20 ℃; for 3h;

Reference yield:

: 74668-74-9
2-chloro-8-methoxy-quinoline

: 1065481-72-2
3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane / 1.25 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

4.1: thionyl chloride / chloroform / 3 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; chloroform; cyclohexane; water; acetonitrile;

Reference yield:

: 73568-28-2
2-chloro-8-methoxyquinoline-3-carbaldehyde

: 1065481-72-2
3-(chloromethyl)-2-(3-fluorophenyl)-8-methoxyquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

2: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

3: thionyl chloride / chloroform / 3 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; chloroform; water; acetonitrile;