4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

Base Information

Chemical Name:4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride
CAS No.:1414358-14-7
Molecular Formula:C₂₇H₂₇FN₈O₂*ClH
Molecular Weight:551.023
Hs Code.:

Synonyms:4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

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Chemical Property of 4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

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Technology Process of 4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

There total 11 articles about 4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1558050-43-3
tert-butyl N-[4-[[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]amino]-3-cyano-1,1-dimethyl-4-oxo-but-2-enyl]carbamate

: 1414358-14-7
4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; for 96h;

Reference yield:

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1414358-14-7
4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 h / 20 °C / Cooling with ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.17 h / 140 °C / Microwave irradiation

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h / 20 °C

4: HATU; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

5: piperidine / ethanol / 2 h / 110 °C / Sealed tube

6: hydrogenchloride / 1,4-dioxane; methanol / 96 h

With piperidine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 121219-03-2
4-bromo-3-fluorophenol

: 1414358-14-7
4-amino-N-[(1R)-2-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-methyl-ethyl]-2-cyano-4-methyl-pent-2-enamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -80 - -70 °C / Inert atmosphere

2.2: 2 h / -80 - -70 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 0.17 h / 140 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h / 20 °C

5.1: HATU; triethylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: piperidine / ethanol / 2 h / 110 °C / Sealed tube

7.1: hydrogenchloride / 1,4-dioxane; methanol / 96 h

With piperidine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; copper diacetate; potassium carbonate; triethylamine; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;