N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Base Information

Chemical Name:N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide
CAS No.:1055925-88-6
Molecular Formula:C₂₇H₃₆N₁₀O
Molecular Weight:516.649
Hs Code.:

Synonyms:N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

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Chemical Property of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

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Technology Process of N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

There total 11 articles about N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055927-86-0
3-(4-methyl-1-piperazinyl) benzoyl chloride

: 1055927-46-2
6-(1-cyclopentylhydrazino)-9-[2-(dimethylamino)ethyl]-9H-purine-2-carbonitrile

: 1055925-88-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1055926-56-1
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclopentylhydrazinecarboxylate

: 1055925-88-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

2: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

3: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 44 h / 20 - 100 °C

4: water; acetonitrile

5: toluene-4-sulfonic acid / acetonitrile / 64 h / 20 °C

6: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 20419-68-5
2,6-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine

: 1055925-88-6
N'-{2-cyano-9-[2-(dimethylamino)ethyl]-9H-purin-6-yl}-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Heating / reflux

2: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation

3: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux

4: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 44 h / 20 - 100 °C

5: water; acetonitrile

6: toluene-4-sulfonic acid / acetonitrile / 64 h / 20 °C

7: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;