1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

Base Information

Chemical Name:1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene
CAS No.:691881-18-2
Molecular Formula:C₁₉H₂₄N₂OS
Molecular Weight:328.478
Hs Code.:

Synonyms:1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

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Chemical Property of 1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

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Technology Process of 1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

There total 3 articles about 1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 691881-17-1
3-cyclohexyl-1-(3-hydroxypropyl)-4-(4-methylthiophenyl)pyrazol-5-ol

: 691881-18-2
1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

Guidance literature:: With polymer supported triphenylphosphine; carbon tetrabromide; In N,N-dimethyl-formamide; at 20 ℃; for 120h;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 70290-37-8
(4-methylsulfanyl-phenyl)-acetic acid methyl ester

: 691881-18-2
1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

2.1: 52 percent / glacial AcOH / 1 h / 100 °C

3.1: 53 percent / polymer supported triphenylphosphine; carbon tetrabromide / dimethylformamide / 120 h / 20 °C

With polymer supported triphenylphosphine; carbon tetrabromide; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 691881-03-5
methyl 3-cyclohexyl-2-(4-methylthiophenyl)-3-oxo-propanoate

: 691881-18-2
1-(2-cyclohexyl-(5H,6H,7H-pyrazolo[5,1-b]1,3-oxazaperhydroin-3-yl))-4-methylthiobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / glacial AcOH / 1 h / 100 °C

2: 53 percent / polymer supported triphenylphosphine; carbon tetrabromide / dimethylformamide / 120 h / 20 °C

With polymer supported triphenylphosphine; carbon tetrabromide; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.01.012