6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid

Base Information

• Chemical Name: 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid
• CAS No.: 479490-43-2
• Molecular Formula: C₁₉H₂₃NO₆
• Molecular Weight: 361.395

Synonyms:6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid

Chemical Property of 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid

Chemical Property:

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Technology Process of 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid

There total 3 articles about 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester (479490-65-8) → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid (479490-43-2)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 20 ℃; for 18h;

DOI:10.1021/jo020433f

Reference yield:

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one (103201-79-2,1820583-17-2) → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid (479490-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaN(TMS)2 / tetrahydrofuran / 1.5 h / -5 - 0 °C

2: tetrahydrofuran / 1.5 h / 20 °C

3: aq. NaOH / acetonitrile / 18 h / 20 °C

With sodium hydroxide; sodium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo020433f

Reference yield:

Sodium; ethoxy-[(3R,7aS)-5-oxo-3-phenyl-dihydro-pyrrolo[1,2-c]oxazol-(6E)-ylidene]-methanolate → 6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid (479490-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.5 h / 20 °C

2: aq. NaOH / acetonitrile / 18 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jo020433f

upstream raw materials:

6-tert-butoxycarbonylmethyl-5-oxo-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazole-6-carboxylic acid ethyl ester

(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Downstream raw materials:

(2R,5S,7S)-7-(tert-butyloxycarbonylmethyl)-8-oxo-2-phenyl-1-aza-3-oxa-bicyclo[3.3.0]octane

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