(1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone

Base Information

• Chemical Name: (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone
• CAS No.: 1227065-24-8
• Molecular Formula: C₁₈H₁₁ClN₄O₂
• Molecular Weight: 350.764
• Mol file: 1227065-24-8.mol

Synonyms:(1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone

Chemical Property of (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone

There total 4 articles about (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

ethyl 4-(3-chloropyrazin-2-yloxy)benzoate (1223880-70-3) + 1,2-diamino-benzene (95-54-5) → (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone (1227065-24-8)

Guidance literature:

ethyl 4-(3-chloropyrazin-2-yloxy)benzoate; 1,2-diamino-benzene; With orthoformic acid triethyl ester; benzenesulfonic acid; In tetrahydrofuran; toluene; for 4h; Reflux;

With lithium diisopropyl amide; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 3h;

DOI:10.1021/jm401234w

Reference yield:

ethyl 4-(3-chloropyrazin-2-yloxy)benzoate (1223880-70-3) + orthoformic acid triethyl ester (122-51-0) + 1,2-diamino-benzene (95-54-5) → (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone (1227065-24-8)

Guidance literature:

orthoformic acid triethyl ester; 1,2-diamino-benzene; With benzenesulfonic acid; In toluene; for 4h; Reflux;

ethyl 4-(3-chloropyrazin-2-yloxy)benzoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

2,3-dichloropyrazine (4858-85-9) + (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone (1227060-00-5) → (1H-benzo[d]imidazol-2-yl)(4-((3-chloropyrazin-2-yl)oxy)phenyl)methanone (1227065-24-8)

Guidance literature:

With potassium carbonate; N,N-dimethyl-formamide; at 90 ℃; for 18h;

upstream raw materials:

ethyl 4-(3-chloropyrazin-2-yloxy)benzoate

orthoformic acid triethyl ester

1,2-diamino-benzene

2,3-dichloropyrazine

Downstream raw materials:

(1H-benzo[d]imidazol-2-yl)(4-(3-morpholinopyrazin-2-yloxy)phenyl)methanone

(1H-benzo[d]imidazol-2-yl)(4-(3-(2-fluoropyridin-3-yl)pyrazin-2-yloxy)phenyl)methanone

1H-benzimidazol-2-yl(4-((3-(4-((tert-butyl(dimethyl)silyl)oxy)-1-cyclohexen-1-yl)-2-pyrazinyl)oxy)phenyl)methanone

(1H-benzo[d]imidazol-2-yl)(4-(3-propoxypyrazin-2-yloxy)phenyl)methanone