3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

Base Information

Chemical Name:3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride
CAS No.:1234366-99-4
Molecular Formula:C₁₆H₁₄Cl₃NO₂S*ClH
Molecular Weight:427.179
Hs Code.:

Synonyms:3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

Suppliers and Price of 3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

There total 2 articles about 3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1234366-98-3
4-(3-benzylsulfanylphenyl)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinoline

: 1234366-99-4
3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

Guidance literature:: With water; chlorine; In acetic acid; at 20 ℃; for 1h;

Reference yield:

: 543737-10-6,1870821-29-6
4-(3-bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 1234366-99-4
3-(6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl)benzenesulfonyl chloride hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 15 °C / Inert atmosphere

1.2: 12 h / 140 °C / Inert atmosphere

2.1: acetic acid; 1,3-dichloro-5,5-dimethylhydantoin / water; acetonitrile / 2 h / 0 - 5 °C

2.2: 0.5 h

With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 5,5-dimethyl-1,3-cyclohexadiene; water; acetonitrile;