1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Base Information

Chemical Name:1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole
CAS No.:124750-55-6
Molecular Formula:C₂₆H₃₂N₂O₃
Molecular Weight:420.552
Hs Code.:

Synonyms:1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Suppliers and Price of 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

There total 14 articles about 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 124750-54-5
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-4-methyl-2-propylimidazole-5-carboxaldehyde

: 124750-55-6
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 25 ℃; for 1.5h;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 124750-55-6
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

4: tetrahydrofuran / 1 h / 25 °C

5: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

6: potassium carbonate / dimethylformamide / 24 h / 25 °C

7: 96 percent / sodium borohydride / methanol; tetrahydrofuran / 1.5 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 124750-55-6
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

2: tetrahydrofuran / 1 h / 25 °C

3: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

4: potassium carbonate / dimethylformamide / 24 h / 25 °C

5: 96 percent / sodium borohydride / methanol; tetrahydrofuran / 1.5 h / 25 °C

With sodium tetrahydroborate; N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031