(S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate

Base Information

• Chemical Name: (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate
• CAS No.: 613675-78-8
• Molecular Formula: C₂₄H₂₉N₃O₃
• Molecular Weight: 407.513

Synonyms:(S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate

Chemical Property of (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate

There total 5 articles about (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + phenethylamine (64-04-0) + 3-(1H-indol-3-yl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid (613675-98-2) → (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate (613675-78-8)

Guidance literature:

phenethylamine; 3-(1H-indol-3-yl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; In N,N-dimethyl-formamide; for 1.5h;

DOI:10.1246/cl.2003.830

Reference yield: 68.0%

Boc-Trp-OH (13139-14-5) + phenethylamine (64-04-0) → (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate (613675-78-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/cmdc.201402428

Reference yield:

2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate (3392-11-8) + phenethylamine (64-04-0) → (S)-tert-butyl (3-(1H-indol-3-yl)-1-oxo-1-(phenethylamino)propan-2-yl)carbamate (613675-78-8)

Guidance literature:

In 1,2-dimethoxyethane; at 20 ℃; for 2h;

DOI:10.1021/jm000937a

upstream raw materials:

2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tryptophanate

phenethylamine

di-tert-butyl dicarbonate

3-(1H-indol-3-yl)-2-(4-nitro-phenoxycarbonylamino)-propionic acid

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