C₁₆H₁₈FIO₂S

Base Information

• Chemical Name: C₁₆H₁₈FIO₂S
• CAS No.: 1103451-92-8
• Molecular Formula: C₁₆H₁₈FIO₂S
• Molecular Weight: 420.287
• Mol file: 1103451-92-8.mol

Synonyms:C₁₆H₁₈FIO₂S

Chemical Property of C₁₆H₁₈FIO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₈FIO₂S

There total 3 articles about C₁₆H₁₈FIO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

C5H7FI2 (1103451-84-8) + (5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one (184435-75-4) → C16H18FIO2S (1103451-92-8)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.10.069

Reference yield:

5-iodo-4-penten-1-al (102968-73-0) → C16H18FIO2S (1103451-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (R)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; N-fluorobis(benzenesulfon)imide / tetrahydrofuran; isopropyl alcohol / -10 °C

1.2: 20 °C

2.1: iodine; triphenylphosphine / N,N-dimethyl-formamide / 100 °C

3.1: potassium tert-butylate / dimethyl sulfoxide / 20 h / 20 °C

With (R)-5-benzyl-2,2,3,-trimethylimidazolidin-4-one dichloroacetic acid salt; potassium tert-butylate; iodine; N-fluorobis(benzenesulfon)imide; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Appel Halogenation;

DOI:10.1248/cpb.c20-00223

Reference yield:

C5H8FIO (1103451-91-7) → C16H18FIO2S (1103451-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; triphenylphosphine / N,N-dimethyl-formamide / 100 °C

2: potassium tert-butylate / dimethyl sulfoxide / 20 h / 20 °C

With potassium tert-butylate; iodine; triphenylphosphine; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1: |Appel Halogenation;

DOI:10.1248/cpb.c20-00223

upstream raw materials:

C₅H₇FI₂

(5S)-5-methyl-3-phenylsulfanyl-4,5-dihydrofuran-2(3H)-one

5-iodo-4-penten-1-al

C₅H₈FIO