Technology Process of tert-butyl ((3aR,5S,6R,7R,7aR)-6-(benzyloxy)-7-fluoro-5-formyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-2-yl)(ethyl)carbamate
There total 10 articles about tert-butyl ((3aR,5S,6R,7R,7aR)-6-(benzyloxy)-7-fluoro-5-formyl-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-2-yl)(ethyl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: triethylamine / methanol / 10 h / 25 °C
2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 0 - 20 °C
3: diethylamino-sulfur trifluoride / dichloromethane / 48 h / -78 - 20 °C / Inert atmosphere
4: potassium carbonate; methanol / 3 h / 0 - 20 °C
5: 1H-imidazole / N,N-dimethyl-formamide / 72 h / 20 °C
6: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 0 - 20 °C
7: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
8: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C
With
1H-imidazole; methanol; dmap; diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate; methanol / 3 h / 0 - 20 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 72 h / 20 °C
3: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 0 - 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
5: Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C
With
1H-imidazole; methanol; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
![tert-butyl ((3aR,5R,6R,7R,7aR)-6-(benzyloxy)-7-fluoro-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazol-2-yl)(ethyl)carbamate](/Databaselist/images/loading.webp)
