Technology Process of methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate
There total 10 articles about methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4.3 g / sodium borohydride / tetrahydrofuran / 3.5 h / 20 °C
2: triethylamine / CH2Cl2 / 0.17 h / 20 °C
3: sodium azide / dimethylformamide / 14 h / 80 °C
4: hydrogen / Pd/C / dioxane; H2O / 10 h / 20 °C
5: ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C
With
sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.062
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 91 percent / sulfuric acid / 1.5 h / Heating
2.1: hydrogen / Pd/C / methanol / 23.5 h / 20 °C
3.1: p-toluenesulfonic acid monohydrate / methanol / 7 h / 65 °C
3.2: formic acid / H2O / 2 h / 20 °C
4.1: 4.3 g / sodium borohydride / tetrahydrofuran / 3.5 h / 20 °C
5.1: triethylamine / CH2Cl2 / 0.17 h / 20 °C
6.1: sodium azide / dimethylformamide / 14 h / 80 °C
7.1: hydrogen / Pd/C / dioxane; H2O / 10 h / 20 °C
8.1: ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C
With
sodium tetrahydroborate; sodium azide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.062
