methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

Base Information

Chemical Name:methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate
CAS No.:334792-92-6
Molecular Formula:C₁₈H₁₉F₃N₄O₂
Molecular Weight:380.37
Hs Code.:

Synonyms:methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

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Chemical Property of methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

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Technology Process of methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

There total 10 articles about methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 334792-92-6
methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

Guidance literature:

Reference yield:

: 334792-87-9
Methyl 3-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)benzoate

: 334792-92-6
methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 4.3 g / sodium borohydride / tetrahydrofuran / 3.5 h / 20 °C

2: triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

3: sodium azide / dimethylformamide / 14 h / 80 °C

4: hydrogen / Pd/C / dioxane; H₂O / 10 h / 20 °C

5: ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C

With sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.062

Reference yield:

: 328-80-3
3-nitro-5-trifluoromethyl-benzoic acid

: 334792-92-6
methyl 3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 91 percent / sulfuric acid / 1.5 h / Heating

2.1: hydrogen / Pd/C / methanol / 23.5 h / 20 °C

3.1: p-toluenesulfonic acid monohydrate / methanol / 7 h / 65 °C

3.2: formic acid / H₂O / 2 h / 20 °C

4.1: 4.3 g / sodium borohydride / tetrahydrofuran / 3.5 h / 20 °C

5.1: triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

6.1: sodium azide / dimethylformamide / 14 h / 80 °C

7.1: hydrogen / Pd/C / dioxane; H₂O / 10 h / 20 °C

8.1: ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C

With sodium tetrahydroborate; sodium azide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.01.062