ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

Base Information

Chemical Name:ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate
CAS No.:1489134-73-7
Molecular Formula:C₂₃H₂₃N₃O₃S
Molecular Weight:421.52
Hs Code.:

Synonyms:ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

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Chemical Property of ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

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Technology Process of ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

There total 4 articles about ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1489134-62-4
2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1489134-73-7
ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

Guidance literature:: 2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.0833333h; Inert atmosphere;

ethyl β-alaninate hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.08.024

Reference yield:

: ethyl 2-methyl-4-(phenyl)-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylate

: 1489134-73-7
ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 2 h / Reflux

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.08.024

Reference yield:

: 136-95-8,102337-98-4,84293-42-5
2-amino-benzthiazole

: 1489134-73-7
ethyl-3-(2-methyl-4-phenyl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate / ethylene glycol / 1 h / 20 - 120 °C

2.1: potassium hydroxide / ethanol / 2 h / Reflux

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; ethylene glycol;
DOI:10.1016/j.ejmech.2013.08.024