acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

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Chemical Name:acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester
CAS No.:405939-47-1
Molecular Formula:C₂₉H₃₂ClN₅O₇
Molecular Weight:598.055
Hs Code.:

acetic acid 2-[<i>tert</i>-butoxycarbonyl-(5-{6-[<i>tert</i>-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

Synonyms:acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

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Chemical Property of acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

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Technology Process of acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

There total 4 articles about acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405939-84-6
[6-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrazin-2-yl](3-chlorophenyl)carbamic acid tert-butyl ester

: 13831-31-7
Acetoxyacetyl chloride

: 405939-47-1
acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

Guidance literature:: [6-(5-((tert-butoxycarbonyl)amino)pyridin-3-yl)pyrazin-2-yl](3-chlorophenyl)carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Acetoxyacetyl chloride; In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/jm058205b

Reference yield:

: 405939-83-5
5-{6-[tert-butoxycarbonyl-(3-chlorophenyl)amino]pyrazin-2-yl}nicotinic acid

: 405939-47-1
acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / diphenylphosphoryl azide; triethylamine / toluene / 4.5 h / 70 - 100 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: 70 mg / tetrahydrofuran / 18 h / Heating

With diphenylphosphoranyl azide; sodium hydride; triethylamine; In tetrahydrofuran; toluene; 1.1: Curtius rearrangement;
DOI:10.1021/jm058205b

Reference yield:

: 405939-82-4
5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-nicotinic acid ethyl ester

: 405939-47-1
acetic acid 2-[tert-butoxycarbonyl-(5-{6-[tert-butoxycarbonyl-(3-chloro-phenyl)-amino]-pyrazin-2-yl}-pyridin-3-yl)-amino]-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / aq. NaOH / methanol / 18.3 h / 0 - 20 °C

2.1: 89 percent / diphenylphosphoryl azide; triethylamine / toluene / 4.5 h / 70 - 100 °C

3.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

3.2: 70 mg / tetrahydrofuran / 18 h / Heating

With sodium hydroxide; diphenylphosphoranyl azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; toluene; 2.1: Curtius rearrangement;
DOI:10.1021/jm058205b