{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

Base Information

Chemical Name:{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid
CAS No.:1450727-70-4
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

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Chemical Property of {trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

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Technology Process of {trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

There total 4 articles about {trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450727-82-8
C₂₃H₂₅ClN₂O₄

: 1450727-70-4
{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: C₂₃H₂₅ClN₂O₄; With 4-methoxy-benzylamine; triethylamine; In N,N-dimethyl acetamide; at 140 ℃; for 3h; Sealed tube;

With trifluoroacetic acid; at 50 ℃; for 3h; Sealed tube;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 607351-40-6
2,4-dichloropyridine-3-carbonyl chloride

: 1450727-70-4
{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

2.1: hydrogenchloride / water; methanol / 1 h / 20 °C

2.2: 20 h / Reflux

3.1: 4-methoxy-benzylamine; triethylamine / N,N-dimethyl acetamide / 3 h / 140 °C / Sealed tube

3.2: 3 h / 50 °C / Sealed tube

3.3: 20 h / 20 °C

With hydrogenchloride; 4-methoxy-benzylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water;
DOI:10.1016/j.bmc.2013.06.045

Reference yield:

: 1450727-80-6
C₂₉H₄₀Cl₂N₂O₄Si

: 1450727-70-4
{trans-4-[4-(6-amino-5-oxo-2,3-dihydropyrido[3,2-f][1,4]oxazepin-4(5H)-yl)phenyl]cyclohexyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; methanol / 1 h / 20 °C

1.2: 20 h / Reflux

2.1: 4-methoxy-benzylamine; triethylamine / N,N-dimethyl acetamide / 3 h / 140 °C / Sealed tube

2.2: 3 h / 50 °C / Sealed tube

2.3: 20 h / 20 °C

With hydrogenchloride; 4-methoxy-benzylamine; triethylamine; In methanol; N,N-dimethyl acetamide; water;
DOI:10.1016/j.bmc.2013.06.045