carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

Base Information

Chemical Name:carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester
CAS No.:684286-90-6
Molecular Formula:C₃₃H₂₄FN₃O₆
Molecular Weight:577.568
Hs Code.:

Synonyms:carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

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Chemical Property of carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

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Technology Process of carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

There total 1 articles about carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: carbonic acid ethyl ester 7-(4-fluorobenzyl)-9-hydroxy-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester

: 908093-98-1
diazodiphenylmethane

: 684286-90-6
carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

Guidance literature:: In 1,2-dichloro-ethane; at 70 ℃; for 24h;
DOI:10.1016/j.bmcl.2006.05.018

Reference yield: 94.0%

: 684286-90-6
carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

: 684286-91-7
5-benzhydryloxy-7-(4-fluorobenzyl)-9-hydroxy-pyrrolo[3,4-g]quinoxaline-6,8-dione

Guidance literature:: With dmap; potassium carbonate; In tetrahydrofuran; for 18h;
DOI:10.1016/j.bmcl.2006.05.018

Reference yield:

: 684286-90-6
carbonic acid 9-benzhydryloxy-7-(4-fluorobenzyl)-6,8-dioxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinoxalin-5-yl ester ethyl ester

: 7-(4-fluorobenzyl)-5-hydroxy-9-methoxy-7,8-dihydro-pyrrolo[3,4-g]quinoxalin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / aq. K₂CO₃; DMAP / tetrahydrofuran / 18 h

2: 78 percent / K₂CO₃ / dimethylformamide / 16 h

3: 34 percent / NaBH₄ / CH₂Cl₂; methanol / 1 h

4: 38 percent / triethylsilane; TFA / CH₂Cl₂ / 1 h

With triethylsilane; dmap; sodium tetrahydroborate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.018