5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

Base Information

Chemical Name:5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol
CAS No.:1421355-38-5
Molecular Formula:C₂₆H₂₁N₃O₃S
Molecular Weight:455.537
Hs Code.:

Synonyms:5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

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Chemical Property of 5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

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Technology Process of 5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

There total 5 articles about 5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1421355-34-1
C₂₄H₁₇NO₅S

: 107-15-3,85404-18-8
ethylenediamine

: 1421355-38-5
5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

Guidance literature:: With sulfuric acid; silica gel; In ethyl acetate; at 50 ℃; for 2h;
DOI:10.1016/j.bioorg.2012.10.003

Reference yield:

: 1421355-30-7
8-((tert-butyldimethylsilyl)oxy)quinoline-5-sulfonic acid

: 1421355-38-5
5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

2.1: sodium methylate / 1 h / 50 °C

2.2: 7 h / 100 °C

3.1: hydrogenchloride / water / Inert atmosphere; Reflux

4.1: silica gel; sulfuric acid / ethyl acetate / 2 h / 50 °C

With hydrogenchloride; thionyl chloride; sulfuric acid; sodium methylate; silica gel; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bioorg.2012.10.003

Reference yield:

: 1421355-33-0
2-((8-((tert-butyldimethylsilyl)oxy)quinolin-5-yl)sulfonyl)-1,3-diphenylpropane-1,3-dione

: 1421355-38-5
5-((5,7-diphenyl-3,6-dihydro-2H-1,4-diazepin-6-yl)sulfonyl)quinolin-8-ol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / Inert atmosphere; Reflux

2: silica gel; sulfuric acid / ethyl acetate / 2 h / 50 °C

With hydrogenchloride; sulfuric acid; silica gel; In water; ethyl acetate;
DOI:10.1016/j.bioorg.2012.10.003