tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate
CAS No.:1201581-85-2
Molecular Formula:C₁₇H₂₂ClNO₂
Molecular Weight:307.82
Hs Code.:

Synonyms:tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73365-02-3,117625-90-8
tert-butoxycarbonyl-D-prolinal

: 78055-64-8
(3-chlorobenzyl)phosphonic acid ethyl ester

: 1201581-85-2
tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

Guidance literature:: (3-chlorobenzyl)phosphonic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

tert-butoxycarbonyl-D-prolinal; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201581-85-2
tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tert-butyl alcohol / 21 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 3 h / -78 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl alcohol;

Reference yield:

: 344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7
D-Prolin

: 1201581-85-2
tert-butyl (R)-2-[(E)-2-(3-chlorophenyl)vinyl]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tert-butyl alcohol / 21 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 3 h / -78 - 20 °C

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl alcohol;