(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Base Information

Chemical Name:(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride
CAS No.:139056-99-8
Molecular Formula:C₁₇H₂₅NO₃*ClH
Molecular Weight:327.851
Hs Code.:

Synonyms:(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Suppliers and Price of (2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

There total 12 articles about (2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130914-10-2
Methyl (4S,5R)-3-benzyl-4-cyclohexylmethyloxazolidin-2-one-5-carboxylate

: 139056-99-8
(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Guidance literature:: With hydrogenchloride; sodium hydroxide; In methanol; water; at 90 ℃;
DOI:10.1016/S0040-4039(00)97574-9

Reference yield:

: 130914-05-5
(4R,5R)-4-Benzyliminomethyl-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 139056-99-8
(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1) CeCl₃ / 1) THF, Et₂O, 0.5 h, -30 deg C, 2) THF, a) 2 h, -30 deg C, b) 12 h, r.t.

2: 97 percent / K₂CO₃ / tetrahydrofuran / 7 h / 0 °C

3: 80percent AcOH / 5 h / 80 °C

4: KOH / methanol / 3.5 h / Ambient temperature

5: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 760 Torr / Ambient temperature

6: NaIO₄, RuCl₃*3H₂O / acetonitrile; CCl₄; H₂O / 2 h / Ambient temperature

7: methanol; toluene / 1 h / Ambient temperature

8: NaOH / methanol / 90 °C

With ruthenium trichloride; potassium hydroxide; sodium hydroxide; sodium periodate; cerium(III) chloride; hydrogen; potassium carbonate; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; toluene; acetonitrile;
DOI:10.1248/cpb.39.2550

Reference yield:

: 130914-06-6
(4R,5R)-4-<(S)-(1-N-Benzylamino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane

: 139056-99-8
(2R,3S)-3-Benzylamino-4-cyclohexyl-2-hydroxybutyric acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / K₂CO₃ / tetrahydrofuran / 7 h / 0 °C

2: 80percent AcOH / 5 h / 80 °C

3: KOH / methanol / 3.5 h / Ambient temperature

4: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 760 Torr / Ambient temperature

5: NaIO₄, RuCl₃*3H₂O / acetonitrile; CCl₄; H₂O / 2 h / Ambient temperature

6: methanol; toluene / 1 h / Ambient temperature

7: NaOH / methanol / 90 °C

With ruthenium trichloride; potassium hydroxide; sodium hydroxide; sodium periodate; hydrogen; potassium carbonate; acetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; water; toluene; acetonitrile;
DOI:10.1248/cpb.39.2550